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Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial.


ABSTRACT:

Importance

In observational studies, increased water intake is associated with better kidney function.

Objective

To determine the effect of coaching to increase water intake on kidney function in adults with chronic kidney disease.

Design, setting, and participants

The CKD WIT (Chronic Kidney Disease Water Intake Trial) randomized clinical trial was conducted in 9 centers in Ontario, Canada, from 2013 until 2017 (last day of follow-up, May 25, 2017). Patients had stage 3 chronic kidney disease (estimated glomerular filtration rate [eGFR] 30-60 mL/min/1.73 m2 and microalbuminuria or macroalbuminuria) and a 24-hour urine volume of less than 3.0 L.

Interventions

Patients in the hydration group (n = 316) were coached to drink more water, and those in the control group (n = 315) were coached to maintain usual intake.

Main outcomes and measures

The primary outcome was change in kidney function (eGFR from baseline to 12 months). Secondary outcomes included 1-year change in plasma copeptin concentration, creatinine clearance, 24-hour urine albumin, and patient-reported overall quality of health (0 [worst possible] to 10 [best possible]).

Results

Of 631 randomized patients (mean age, 65.0 years; men, 63.4%; mean eGFR, 43 mL/min/1.73 m2; median urine albumin, 123 mg/d), 12 died (hydration group [n = 5]; control group [n = 7]). Among 590 survivors with 1-year follow-up measurements (95% of 619), the mean change in 24-hour urine volume was 0.6 L per day higher in the hydration group (95% CI, 0.5 to 0.7; P < .001). The mean change in eGFR was -2.2 mL/min/1.73 m2 in the hydration group and -1.9 mL/min/1.73 m2 in the control group (adjusted between-group difference, -0.3 mL/min/1.73 m2 [95% CI, -1.8 to 1.2; P = .74]). The mean between-group differences (hydration vs control) in secondary outcomes were as follows: plasma copeptin, -2.2 pmol/L (95% CI, -3.9 to -0.5; P = .01); creatinine clearance, 3.6 mL/min/1.73 m2 (95% CI, 0.8 to 6.4; P = .01); urine albumin, 7 mg per day (95% CI, -4 to 51; P = .11); and quality of health, 0.2 points (95% CI, -0.3 to 0.3; P = .22).

Conclusions and relevance

Among adults with chronic kidney disease, coaching to increase water intake compared with coaching to maintain the same water intake did not significantly slow the decline in kidney function after 1 year. However, the study may have been underpowered to detect a clinically important difference.

Trial registration

clinicaltrials.gov Identifier: NCT01766687.

SUBMITTER: Clark WF 

PROVIDER: S-EPMC6583759 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial.

Clark William F WF   Sontrop Jessica M JM   Huang Shih-Han SH   Gallo Kerri K   Moist Louise L   House Andrew A AA   Cuerden Meaghan S MS   Weir Matthew A MA   Bagga Amit A   Brimble Scott S   Burke Andrew A   Muirhead Norman N   Pandeya Sanjay S   Garg Amit X AX  

JAMA 20180501 18


<h4>Importance</h4>In observational studies, increased water intake is associated with better kidney function.<h4>Objective</h4>To determine the effect of coaching to increase water intake on kidney function in adults with chronic kidney disease.<h4>Design, setting, and participants</h4>The CKD WIT (Chronic Kidney Disease Water Intake Trial) randomized clinical trial was conducted in 9 centers in Ontario, Canada, from 2013 until 2017 (last day of follow-up, May 25, 2017). Patients had stage 3 ch  ...[more]

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