Ontology highlight
ABSTRACT:
SUBMITTER: Beeler JS
PROVIDER: S-EPMC6583996 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Beeler J Scott JS Marshall Clayton B CB Gonzalez-Ericsson Paula I PI Shaver Timothy M TM Santos Guasch Gabriela L GL Lea Spencer T ST Johnson Kimberly N KN Jin Hailing H Venters Bryan J BJ Sanders Melinda E ME Pietenpol Jennifer A JA
PloS one 20190619 6
p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal cells and can heterodimerize with p63. p73-/- mice lack multiciliated cells and have reduced numbers of basal epithelial cells in select tissues; however, the role of p73 in basal epithelial cells is unknown. Herein, we show that p73-deficient mice exhibit delayed wound heali ...[more]