Ontology highlight
ABSTRACT:
SUBMITTER: Hadjivasiliou Z
PROVIDER: S-EPMC6584357 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hadjivasiliou Zena Z Moore Rachel E RE McIntosh Rebecca R Galea Gabriel L GL Clarke Jonathan D W JDW Alexandre Paula P
Developmental cell 20190601 6
During early spinal cord development, neurons of particular subtypes differentiate with a sparse periodic pattern while later neurons differentiate in the intervening space to eventually produce continuous columns of similar neurons. The mechanisms that regulate this spatiotemporal pattern are unknown. In vivo imaging in zebrafish reveals that differentiating spinal neurons transiently extend two long protrusions along the basal surface of the spinal cord before axon initiation. These protrusion ...[more]