Ontology highlight
ABSTRACT:
SUBMITTER: Yen TJ
PROVIDER: S-EPMC6584486 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yen Tien-Jui TJ Lolicato Marco M Thomas-Tran Rhiannon R Du Bois J J Minor Daniel L DL
Science advances 20190619 6
Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble STX-binding proteins that may prevent STX intoxication. However, their STX molecular recognition mechanisms remain unknown. Here, we present structures of saxiphilin (Sxph), a bullfrog high-affinity STX-binding protein, alone and bound to STX. The structures reveal a novel high-affinity STX-binding site built from a "proto-pocket" ...[more]