Ontology highlight
ABSTRACT:
SUBMITTER: Jing Q
PROVIDER: S-EPMC6584592 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Jing Qiancheng Q Li Guo G Chen Xiyu X Liu Chao C Lu Shanhong S Zheng Hua H Ma Huiling H Qin Yuexiang Y Zhang Diekuo D Zhang Shuiting S Ren Shuling S Huang Donghai D Tan Pingqing P Chen Jie J Qiu Yuanzheng Y Liu Yong Y
Journal of cellular and molecular medicine 20190521 7
The canonical Wnt/β-catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt-mediated autophagy in cancer radioresistance remains unclear. In this study, we found that irradiation activated the Wnt/β-catenin and autophagic signalling pathways in squamous cell carcinoma of the head and neck (SCCHN). Wnt3a is a classical ligand that activated the Wnt/β-catenin signalling pathway, induced autophagy and decreased the sensitivity of SCCHN to irradia ...[more]