Dataset Information

Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.

ABSTRACT: Introduction:Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well-characterized AD and control participants, considering ophthalmological confounders. Methods:We included 57 amyloid-proven AD cases and 85 cognitively normal, amyloid-negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomography and an ophthalmological assessment to exclude ocular disease. Results:Retinal thickness did not discriminate cases from controls, including stratified analyses for early- versus late-onset AD. We found significant associations between macular thickness and global cortical atrophy [? -0.358; P = .01] and parietal cortical atrophy on magnetic resonance imaging [? -0.371; P < .01] in AD cases. Discussion:In this study, representing the largest optical coherence tomography cohort with amyloid-proven AD cases, we show that retinal thickness does not discriminate AD from controls, despite evident changes on clinical, neuroimaging, and CSF measures, querying the use of retinal thickness measurements as an AD biomarker.

SUBMITTER: Haan JD

PROVIDER: S-EPMC6584766 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.

den Haan Jurre J van de Kreeke Jacoba A JA Konijnenberg Elles E ten Kate Mara M den Braber Anouk A Barkhof Frederik F van Berckel Bart N BN Teunissen Charlotte E CE Scheltens Philip P Visser Pieter Jelle PJ Verbraak Frank D FD Bouwman Femke H FH

Alzheimer's & dementia (Amsterdam, Netherlands) 20190618

<h4>Introduction</h4>Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well-characterized AD and control participants, considering ophthalmological confounders.<h4>Methods</h4>We included 57 amyloid-proven AD cases and 85 cognitively normal, amyloid-negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomograph ...[more]

PMID: 31249859

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Dataset Information

Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.

Publications

Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.

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