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Kawasaki Disease: The Role of Immune Complexes Revisited.


ABSTRACT: Kawasaki disease (KD) is an inflammatory disease in children associated with vasculitis affecting predominantly the coronary arteries and is now the most common cause of acquired heart disease in children in developed countries. The etiology of KD is unknown but epidemiological studies implicate an infectious agent or toxin, which causes disease in genetically predisposed individuals. The presence of immune complexes (ICs) in the serum of children with KD was established in numerous studies during the 1970s and 80s. More recent genetic studies have identified variation in Fc? receptors and genes controlling immunoglobulin production associated with KD. In this review we link the genetic findings and IC studies and suggest a key role for their interaction in pathophysiology of the disease.

SUBMITTER: Menikou S 

PROVIDER: S-EPMC6584825 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Kawasaki Disease: The Role of Immune Complexes Revisited.

Menikou Stephanie S   Langford Paul R PR   Levin Michael M  

Frontiers in immunology 20190612


Kawasaki disease (KD) is an inflammatory disease in children associated with vasculitis affecting predominantly the coronary arteries and is now the most common cause of acquired heart disease in children in developed countries. The etiology of KD is unknown but epidemiological studies implicate an infectious agent or toxin, which causes disease in genetically predisposed individuals. The presence of immune complexes (ICs) in the serum of children with KD was established in numerous studies duri  ...[more]

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