Ontology highlight
ABSTRACT:
SUBMITTER: Serafin DS
PROVIDER: S-EPMC6584946 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Serafin D Stephen DS Allyn Brittney B Sassano Maria F MF Timoshchenko Roman G RG Mattox Daniel D Brozowski Jaime M JM Siderovski David P DP Truong Young K YK Esserman Denise D Tarrant Teresa K TK Billard Matthew J MJ
Molecular immunology 20181218
Chemerin receptor (CMKLR1) is a G protein-coupled receptor (GPCR) implicated in macrophage-mediated inflammation and in several forms of human arthritis. Analogous to other GPCR, CMKLR1 is likely regulated by G protein-coupled receptor kinase (GRK) phosphorylation of intracellular domains in an activation-dependent manner, which leads to recruitment and termination of intracellular signaling via desensitization and internalization of the receptor. The ubiquitously expressed GRK family members in ...[more]