Genetic and observational evidence supports a causal role of sex hormones on the development of asthma.

ABSTRACT:

Introduction

Males have a higher prevalence of asthma in childhood, whereas females have a higher prevalence in adolescence and adulthood. The 'adolescent switch' observed between sexes during puberty has been hypothesised to be due to fluctuating sex hormones. Robust evidence of the involvement of sex hormones in asthma could lead to development of therapeutic interventions.

Methods

We combine observational evidence using longitudinal data on sex hormone-binding globulin (SHBG), total and bioavailable testosterone and asthma from a subset of males (n=512) in the Avon Longitudinal Study of Parents and Children, and genetic evidence of SHBG and asthma using two-sample Mendelian randomisation (MR), a method of causal inference. We meta-analysed two-sample MR results across two

SUBMITTER: Arathimos R 

PROVIDER: S-EPMC6585308 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature