Effect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials.

ABSTRACT:

Purpose

The study sought to summarize the evidence of pre-procedural atorvastatin therapy to improve the prognosis of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).

Patients and methods

We searched PubMed and Embase from inception to July 2018 for randomized controlled trials that compared loading dose atorvastatin pretreatment with no or low dose for the prevention of cardiovascular events. The primary end points were all-cause mortality and myocardial infarction (MI) at 30 days. The secondary end point was 30-day major adverse cardiovascular events (MACE), a composite of all-cause mortality, MI, and revascularization.

Results

Six trials with 4,991 individuals were included in our meta-analysis. High-dose atorvastatin prel

SUBMITTER: Ma M 

PROVIDER: S-EPMC6585398 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature