Ontology highlight
ABSTRACT:
SUBMITTER: Wang A
PROVIDER: S-EPMC6585460 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wang Anqi A Venditto Nicholas J NJ Darcy Julia W JW Emmert Marion H MH
Organometallics 20170323 7
This work demonstrates the use of hydroxylamine-based amination reagents RSO<sub>2</sub>NH-OAc for the nondirected, Cu-catalyzed amination of benzylic C-H bonds. The amination reagents can be prepared on a gram scale, are benchtop stable, and provide benzylic C-H amination products with up to 86% yield. Mechanistic studies of the established reactivity with toluene as substrate reveal a ligand-promoted, Cu-catalyzed mechanism proceeding through Ph-CH<sub>2</sub>(NTsOAc) as a major intermediate. ...[more]