Multi-modal functional MRI to explore placental function over gestation.
Ontology highlight
ABSTRACT: Purpose
To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ.Methods
Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia.Results
A multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation.Conclusions
The obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
SUBMITTER: Hutter J
PROVIDER: S-EPMC6585747 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Multi-modal functional MRI to explore placental function over gestation.
Hutter Jana J Slator Paddy J PJ Jackson Laurence L Gomes Ana Dos Santos ADS Ho Alison A Story Lisa L O'Muircheartaigh Jonathan J Teixeira Rui P A G RPAG Chappell Lucy C LC Alexander Daniel C DC Rutherford Mary A MA Hajnal Joseph V JV
Magnetic resonance in medicine 20180921 2
<h4>Purpose</h4>To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ.<h4>Methods</h4>Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two preg ...[more]
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