A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode.

ABSTRACT:

Objectives

There is evidence that the gut microbiota plays a major role in the pathogenesis of diseases of the central nervous system through the gut-brain axis. The aim of the present study was to analyze gut microbiota composition in bipolar disorder (BD) and its relation to inflammation, serum lipids, oxidative stress, tryptophan (TRP)/kynurenine (KYN) levels, anthropometric measurements and parameters of metabolic syndrome. Further, microbial community differences of individuals with BD compared with healthy controls (HC) were explored.

Methods

In this cross-sectional study, we performed 16S rRNA gene sequencing of stool samples from 32 BD individuals and 10 HC. Laboratory parameters included inflammatory markers, serum lipids, KYN, oxidative stress and anthropometric me

SUBMITTER: Painold A 

PROVIDER: S-EPMC6585963 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature