Ontology highlight
ABSTRACT:
SUBMITTER: Besnier M
PROVIDER: S-EPMC6586592 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Besnier Marie M Shantikumar Saran S Anwar Maryam M Dixit Parul P Chamorro-Jorganes Aranzazu A Sweaad Walid W Sala-Newby Graciela G Madeddu Paolo P Thomas Anita C AC Howard Lynsey L Mushtaq Sobia S Petretto Enrico E Caporali Andrea A Emanueli Costanza C
Molecular therapy. Nucleic acids 20190517
MicroRNA-15a (miR-15a) and miR-16, which are transcribed from the miR-15a/miR-16-1 cluster, inhibit post-ischemic angiogenesis. MicroRNA (miRNA) binding to mRNA coding sequences (CDSs) is a newly emerging mechanism of gene expression regulation. We aimed to (1) identify new mediators of the anti-angiogenic action of miR-15a and -16, (2) develop an adenovirus (Ad)-based miR-15a/16 decoy system carrying a luciferase reporter (Luc) to both sense and inhibit miR-15a/16 activity, and (3) investigate ...[more]