Ontology highlight
ABSTRACT:
SUBMITTER: Frisbee AL
PROVIDER: S-EPMC6586630 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Frisbee Alyse L AL Saleh Mahmoud M MM Young Mary K MK Leslie Jhansi L JL Simpson Morgan E ME Abhyankar Mayuresh M MM Cowardin Carrie A CA Ma Jennie Z JZ Pramoonjago Patcharin P Turner Stephen D SD Liou Alice P AP Buonomo Erica L EL Petri William A WA
Nature communications 20190620 1
Clostridium difficile (C. difficile) incidence has tripled over the past 15 years and is attributed to the emergence of hypervirulent strains. While it is clear that C. difficile toxins cause damaging colonic inflammation, the immune mechanisms protecting from tissue damage require further investigation. Through a transcriptome analysis, we identify IL-33 as an immune target upregulated in response to hypervirulent C. difficile. We demonstrate that IL-33 prevents C. difficile-associated mortalit ...[more]