Ontology highlight
ABSTRACT:
SUBMITTER: Qiu C
PROVIDER: S-EPMC6586638 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Qiu Chong C Qiu Chong C Han Hu-Hu HH Sun Jing J Zhang Hai-Tao HT Wei Wei W Cui Shi-He SH Chen Xin X Wang Jian-Cheng JC Zhang Qiang Q
Nature communications 20190620 1
Most cationic vectors are difficult to avoid the fate of small interfering RNA (siRNA) degradation following the endosome-lysosome pathway during siRNA transfection. In this study, the endoplasmic reticulum (ER) membrane isolated from cancer cells was used to fabricate an integrative hybrid nanoplexes (EhCv/siRNA NPs) for improving siRNA transfection. Compared to the undecorated Cv/siEGFR NPs, the ER membrane-decorated EhCv/siRNA NPs exhibits a significantly higher gene silencing effect of siRNA ...[more]