Ontology highlight
ABSTRACT:
SUBMITTER: Alexander LM
PROVIDER: S-EPMC6586675 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Alexander Lisa M LM Goldman Daniel H DH Wee Liang M LM Bustamante Carlos C
Nature communications 20190620 1
Protein folding can begin co-translationally. Due to the difference in timescale between folding and synthesis, co-translational folding is thought to occur at equilibrium for fast-folding domains. In this scenario, the folding kinetics of stalled ribosome-bound nascent chains should match the folding of nascent chains in real time. To test if this assumption is true, we compare the folding of a ribosome-bound, multi-domain calcium-binding protein stalled at different points in translation with ...[more]