Ontology highlight
ABSTRACT:
SUBMITTER: Bogdanova NV
PROVIDER: S-EPMC6587039 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bogdanova Natalia V NV Schürmann Peter P Valova Yana Y Dubrowinskaja Natalia N Turmanov Nurzhan N Yugay Tatyana T Essimsiitova Zura Z Mingazheva Elvira E Prokofyeva Darya D Bermisheva Marina M Khusnutdinova Elza E Dörk Thilo T
Frontiers in oncology 20190614
CDK12 is a member of the cyclin-dependent kinase family that acts as regulator of DNA damage response gene expression. A c.1047-2A>G splice site variant of the <i>CDK12</i> gene was recently reported to strongly associate with hereditary breast and ovarian cancer in patients of Tatar ethnic origin. To gain more insight into the potential risk and the population spread of the c.1047-2A>G variant, we have genotyped three breast cancer case-control series of Tatar, Bashkir and Kazakh ethnicity. We ...[more]