Myocardial flow reserve assessed by cardiac 82Rb positron emission tomography/computed tomography is associated with albumin excretion in patients with Type 1 diabetes.

ABSTRACT: AIMS:To evaluate myocardial flow reserve (MFR) and coronary artery calcium (CAC) in persons with Type 1 diabetes with or without albuminuria and in non-diabetic controls. MFR reflects the function of large epicardial arteries and myocardial microcirculation. CAC represents structural aspects of atherosclerosis. In addition, we evaluated the association of MFR and CAC with retinopathy, another microvascular complication. METHODS AND RESULTS:Cross-sectional study in Type 1 diabetes, stratified by normoalbuminuria (NORMO; n?=?30) and macroalbuminuria (MACRO; n?=?30), and in non-diabetic controls (n?=?30). MFR (pharmacological stress flow/rest flow) was evaluated by cardiac 82Rb positron emission tomography/computed tomography. MFR was similar in patients with NORMO and controls (3.1?±?0.79 vs. 3.0?±?0.79; P?=?0.74). Patients with MACRO had lower (impaired) MFR when compared with NORMO (2.1?±?0.92 vs. 3.1?±?0.79; P?

SUBMITTER: Zobel EH 

PROVIDER: S-EPMC6587116 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature