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ABSTRACT:
SUBMITTER: Matsumoto Y
PROVIDER: S-EPMC6587435 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20181204 4
Pharmacokinetics (PKs) in Japanese healthy subjects were simulated for nine compounds using physiologically based PK (PBPK) models parameterized with physicochemical properties, preclinical absorption, distribution, metabolism, and excretion (ADME) data, and clinical PK data from non-Japanese subjects. For each dosing regimen, 100 virtual trials were simulated and predicted/observed ratios for peak plasma concentration (C<sub>max</sub> ) and area under the curve (AUC) were calculated. As qualifi ...[more]