Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk.

ABSTRACT: Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and overweight. Thus, any variant in energy metabolism-related gene may influence the development of EGJA. In this study, we recruited 720 EGJA cases and 1541 noncancer controls. We selected IGF2BP2 rs4402960 G?>?T, rs1470579 A?>?C, IGF1 rs5742612 A?>?G and IGFBP3 rs3110697 G?>?A, rs2270628 C?>?T and rs6953668 G?>?A loci and assessed the relationship of these polymorphisms with lymph node status and susceptibility of EGJA. We found that IGF2BP2 rs1470579 A?>?C and IGFBP3 rs6953668 G?>?A polymorphisms were associated with the decreased risk of EGJA ( IGF2BP2 rs1470579: CC vs AA: adjusted odds ratio [OR]?=?0.65, 95% confidence interval [CI]?=?0.43-0.98, P?=?0.041 and CC vs AA/AC: adjusted OR?=?0.62, 95% CI?=?0.41-0.93, P?=?0.021 and IGFBP3 rs6953668: GA vs GG: adjusted OR?=?0.66, 95% CI?=?0.47-0.93, P?=?0.019 and GA/AA vs GG: adjusted OR?=?0.68, 95% CI?=?0.48-0.95, P?=?0.026). However, we also found that IGF1 rs5742612 A?>?G polymorphism increased the risk of LNM among patients with EGJA (GG vs AA: adjusted OR?=?1.88, 95% CI?=?1.02-3.46, P?=?0.042 and GG vs AA/AG: adjusted OR?=?1.92, 95% CI?=?1.06-3.47, P?=?0.032). This study suggests that IGF2BP2 rs1470579 A?>?C and IGFBP3 rs6953668 G?>?A polymorphisms may decrease genetic susceptibility to EGJA in eastern Chinese Han population. In addition, our findings also indicate that IGF1 rs5742612 A?>?G polymorphism may increase the susceptibility of LNM among patients with EGJA.

SUBMITTER: Tang W 

PROVIDER: S-EPMC6587846 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature