Ontology highlight
ABSTRACT:
SUBMITTER: Kamermans A
PROVIDER: S-EPMC6587975 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kamermans Alwin A Planting Kirsten E KE Jalink Kees K van Horssen Jack J de Vries Helga E HE
Glia 20181119 1
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS), characterized by inflammation-mediated demyelination, axonal injury and neurodegeneration. The mechanisms underlying impaired neuronal function are not fully understood, but evidence is accumulating that the presence of the gliotic scar produced by reactive astrocytes play a critical role in these detrimental processes. Here, we identified astrocytic Transient Receptor Potential cation channel, subfam ...[more]