Dataset Information

Radio emission from the unbound debris of tidal disruption events.

ABSTRACT: When a star gets too close to a supermassive black hole, it is torn apart by the tidal forces. Roughly half of the stellar mass becomes unbound and flies away at tremendous velocities - around 104 km?s-1. In this work, we explore the idea that the shock produced by the interaction of the unbound debris with the ambient medium gives rise to the synchrotron radio emission observed in several tidal disruption event (TDE). We use a moving mesh numerical simulation to study the evolution of the unbound debris and the bow shock around it. We find that as the periapse distance of the star decreases, the outflow becomes faster and wider. A TDE whose periapse distance is a factor of 7 smaller than the tidal radius can account for the radio emission observed in ASASSN-14li. This model also allows us to obtain a more accurate estimate for the gas density around the centre of the host galaxy of ASASSN-14li.

SUBMITTER: Yalinewich A

PROVIDER: S-EPMC6588130 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Radio emission from the unbound debris of tidal disruption events.

Yalinewich A A Steinberg E E Piran T T Krolik J H JH

Monthly notices of the Royal Astronomical Society 20190610 3

When a star gets too close to a supermassive black hole, it is torn apart by the tidal forces. Roughly half of the stellar mass becomes unbound and flies away at tremendous velocities - around 10<sup>4</sup> km s<sup>-1</sup>. In this work, we explore the idea that the shock produced by the interaction of the unbound debris with the ambient medium gives rise to the synchrotron radio emission observed in several tidal disruption event (TDE). We use a moving mesh numerical simulation to study the ...[more]

PMID: 31258198

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Project description:Imatinib is a first-line drug for the treatment of gastrointestinal stromal tumors (GIST). This study aims to investigate the influence of different kinds of protein concentrations and genetic polymorphisms of metabolizing enzymes and drug transporters on unbound imatinib and its active metabolite N-desmethyl-imatinib concentration, as well as the relationship between adverse drug reactions (ADRs) and drug concentration. A total of 62 Chinese patients with GIST were genotyped for five single nucleotide polymorphisms (SNPs). Total and unbound 3h and trough concentration of imatinib and N-desmethyl-imatinib in GIST patients were determined by an LC-MS/MS method combined with an equilibrium dialysis. Single-Use Red Plate with inserts was used to separate the unbound drug. When the protein concentration became higher, the unbound imatinib and N-desmethyl-imatinib plasma concentration got higher (p < 0.05). Patients with GA genotype in rs755828176 had significantly higher unbound N-desmethyl-imatinib dose-adjusted trough plasma concentrations (p = 0.012). Patients with CC genotype in rs3814055 had significantly higher unbound imatinib dose-adjusted trough plasma concentrations (p = 0.040). The mean total imatinib C3h of patients with ADRs (3.10 ± 0.96 µg/ml) was significantly higher than that of patients without ADRs (p = 0.023). The mean total N-desmethyl-imatinib C3h of patients (0.64 ± 0.21 µg/ml) with ADRs was significantly higher than that of patients without ADRs (p = 0.004). The mean unbound N-desmethyl-imatinib C3h of patients with ADRs (6.49 ± 2.53 ng/ml) was significantly higher than that of patients without ADRs (p = 0.042). The total and unbound C3h of imatinib and N-desmethyl-imatinib in patients with ADRs was significantly higher than that in patients without ADRs (p < 0.05). Protein concentrations have great influence on the unbound imatinib and N-desmethyl-imatinib concentrations. The genetic polymorphisms of CYP3A4 rs755828176 and NR1I2 rs3814055 were significantly associated with unbound imatinib and N-desmethyl-imatinib dose-adjusted trough plasma levels. The total and unbound imatinib or N-desmethyl-imatinib concentration in patients with GIST was also significantly correlated with ADRs.

Dataset Information

Radio emission from the unbound debris of tidal disruption events.

Publications

Radio emission from the unbound debris of tidal disruption events.

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