Ontology highlight
ABSTRACT:
SUBMITTER: Lang F
PROVIDER: S-EPMC6588254 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lang Fengchao F Singh Rajnish Kumar RK Pei Yonggang Y Zhang Shengwei S Sun Kunfeng K Robertson Erle S ES
PLoS pathogens 20190621 6
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. Furthermore, m6A modification demonstrated a functional role in regulation of the stability of viral transcripts. The methyltransferase METTL14 was induced at the transcript and prot ...[more]