Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC6588407 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhou Xiaofei X Yu Jiayi J Cheng Xuhong X Zhao Baoyu B Manyam Ganiraju C GC Zhang Li L Schluns Kimberly K Li Pingwei P Wang Jing J Sun Shao-Cong SC
Nature immunology 20190610 7
CD8<sup>+</sup> T cells and natural killer (NK) cells are central cellular components of immune responses against pathogens and cancer, which rely on interleukin (IL)-15 for homeostasis. Here we show that IL-15 also mediates homeostatic priming of CD8<sup>+</sup> T cells for antigen-stimulated activation, which is controlled by a deubiquitinase, Otub1. IL-15 mediates membrane recruitment of Otub1, which inhibits ubiquitin-dependent activation of AKT, a kinase that is pivotal for T cell activatio ...[more]