Ontology highlight
ABSTRACT:
SUBMITTER: Clister T
PROVIDER: S-EPMC6588460 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Clister Terri T Greenwald Eric C EC Baillie George S GS Zhang Jin J
Cell chemical biology 20190411 6
Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of con ...[more]