Unknown

Dataset Information

0

AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.


ABSTRACT: Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear PKA.

SUBMITTER: Clister T 

PROVIDER: S-EPMC6588460 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.

Clister Terri T   Greenwald Eric C EC   Baillie George S GS   Zhang Jin J  

Cell chemical biology 20190411 6


Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of con  ...[more]

Similar Datasets

| S-EPMC2529053 | biostudies-literature
| S-EPMC2770900 | biostudies-literature
2021-10-11 | GSE154877 | GEO
| S-EPMC3082439 | biostudies-literature
| S-EPMC6175938 | biostudies-literature
2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress
| S-EPMC4226093 | biostudies-literature
| S-EPMC5364530 | biostudies-literature
| S-EPMC6484033 | biostudies-literature
| S-EPMC8328970 | biostudies-literature