Ontology highlight
ABSTRACT:
SUBMITTER: Bertram KM
PROVIDER: S-EPMC6588576 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature communications 20190621 1
Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c<sup>+</sup> dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but are more efficient antigen-presenting cells. Compared to LCs, epidermal CD11c<sup>+</sup> DCs are enriched in anogenital tissues where they preferentially interact with HIV, express the higher levels of HIV entry receptor CCR5, suppor ...[more]