Ontology highlight
ABSTRACT:
SUBMITTER: Piepenbreier H
PROVIDER: S-EPMC6588590 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Piepenbreier Hannah H Diehl Angelika A Fritz Georg G
Nature communications 20190621 1
Cell wall antibiotics are crucial for combatting the emerging wave of resistant bacteria. Yet, our understanding of antibiotic action is limited, as many strains devoid of all resistance determinants display far higher antibiotic tolerance in vivo than suggested by the antibiotic-target binding affinity in vitro. To resolve this conflict, here we develop a comprehensive theory for the bacterial cell wall biosynthetic pathway and study its perturbation by antibiotics. We find that the closed-loop ...[more]