Ontology highlight
ABSTRACT:
SUBMITTER: Yang YM
PROVIDER: S-EPMC6589184 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yang Yoon Mee YM Noureddin Mazen M Liu Cheng C Ohashi Koichiro K Kim So Yeon SY Ramnath Divya D Powell Elizabeth E EE Sweet Matthew J MJ Roh Yoon Seok YS Hsin I-Fang IF Deng Nan N Liu Zhenqiu Z Liang Jiurong J Mena Edward E Shouhed Daniel D Schwabe Robert F RF Jiang Dianhua D Lu Shelly C SC Noble Paul W PW Seki Ekihiro E
Science translational medicine 20190601 496
Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic HA and HA synthase 2 (HAS2) expression was elevated in both human and murine liver fibrosis. HA production and liver fibrosis were reduced in mice lacking HAS2 in hepatic stellate cells (HSCs), whereas mice overexpressing HAS2 had exacerbated liver fibrosis. HAS2 was transcriptionally ...[more]