Ontology highlight
ABSTRACT:
SUBMITTER: Rovai ES
PROVIDER: S-EPMC6589281 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Rovai Emanuel Silva ES Ambrósio Lucas Macedo Batitucci LMB de França Bruno Nunes BN de Oliveira Letícia Rodrigues LR Gasparoni Letícia Miquelitto LM Sipert Carla Renata CR Holzhausen Marinella M
Stem cells international 20190602
Protease-activated receptor 1 (PAR<sub>1</sub>) has been associated to tissue repair and bone healing. The aim of the present study was to evaluate the effect of PAR<sub>1</sub> activation on the osteogenic activity of human periodontal ligament stem cells (PDLSCs). PDLSCs were cultured in the presence of PAR<sub>1</sub>-selective agonist peptide (100 nM), thrombin (0.1 U/mL), or PAR<sub>1</sub> antagonist peptide (100 nM). Calcium deposits, calcium concentration (supernatant), alkaline phosphat ...[more]