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Annotation of a hypothetical protein (WP_002969292.1) from Brucella abortus.

ABSTRACT: Brucellosis is a zoonotic disease caused mainly by the bacteria belonging to the genus Brucella, most common of them is Brucella abortus. Genome sequencing of Brucella was completed in 2005. While majority of the proteins were assigned function, a large number of the peptides remained un-annotated and were referred as 'hypothetical'. These hypothetical proteins may contain crucial information about the biology and pathogenesis of the B. abortus. Therefore, it is of interest to annotate one such hypothetical protein as a multiple antibiotic resistance regulator protein, MarR. The physiological parameters, localization and the structural features were predicted for this protein which corroborated as the winged-helix type DNA-binding domain superfamily of transcription factors.

SUBMITTER: Rauthan K

PROVIDER: S-EPMC6589471 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Annotation of a hypothetical protein (WP_002969292.1) from Brucella abortus.

Rauthan Kanchan K Goel Divya D Kumar Sudhir S

Bioinformation 20190430 5

Brucellosis is a zoonotic disease caused mainly by the bacteria belonging to the genus Brucella, most common of them is Brucella abortus. Genome sequencing of Brucella was completed in 2005. While majority of the proteins were assigned function, a large number of the peptides remained un-annotated and were referred as 'hypothetical'. These hypothetical proteins may contain crucial information about the biology and pathogenesis of the B. abortus. Therefore, it is of interest to annotate one such ...[more]

PMID: 31249433

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