Ontology highlight
ABSTRACT:
SUBMITTER: Shabel SJ
PROVIDER: S-EPMC6589650 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Shabel Steven J SJ Wang Chenyu C Monk Bradley B Aronson Sage S Malinow Roberto R
Proceedings of the National Academy of Sciences of the United States of America 20190531 25
Neuronal activity in the lateral habenula (LHb), a brain region implicated in depression [C. D. Proulx, O. Hikosaka, R. Malinow, <i>Nat. Neurosci.</i> 17, 1146-1152 (2014)], decreases during reward and increases during punishment or reward omission [M. Matsumoto, O. Hikosaka, <i>Nature</i> 447, 1111-1115 (2007)]. While stress is a major risk factor for depression and strongly impacts the LHb, its effect on LHb reward signals is unknown. Here we image LHb neuronal activity in behaving mice and fi ...[more]