Dataset Information

Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.

ABSTRACT:

Background/aims

The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis.

Methods

Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks.

Results

The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture.

Conclusion

Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture.

SUBMITTER: Sharma MK

PROVIDER: S-EPMC6589852 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.

Sharma Manoj Kumar MK Kainth Sumeet S Kumar Sachin S Bhardwaj Ankit A Agarwal Hemant Kumar HK Maiwall Rakhi R Jamwal Kapil Dev KD Shasthry Saggere Muralikrishna SM Jindal Ankur A Choudhary Ashok A Anand Lovkesh L Dhamija Rajender Mal RM Kumar Guresh G Sharma Barjesh Chander BC Sarin Shiv Kumar SK

Clinical and molecular hepatology 20190311 2

<h4>Background/aims</h4>The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis.<h4>Methods</h4>Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks.<h4>Results</h4>The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 recei ...[more]

PMID: 30856689

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Dataset Information

Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.

Background/aims

Methods

Results

Conclusion

Publications

Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.

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