Ontology highlight
ABSTRACT:
SUBMITTER: Kaikkonen E
PROVIDER: S-EPMC6589920 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kaikkonen Elina E Rantapero Tommi T Zhang Qin Q Taimen Pekka P Laitinen Virpi V Kallajoki Markku M Jambulingam Dhanaprakash D Ettala Otto O Knaapila Juha J Boström Peter J PJ Wahlström Gudrun G Sipeky Csilla C Pursiheimo Juha-Pekka JP Tammela Teuvo T Kellokumpu-Lehtinen Pirkko-Liisa PL Fey Vidal V Maehle Lovise L Wiklund Fredrik F Wei Gong-Hong GH Schleutker Johanna J
International journal of cancer 20180922 10
Prostate cancer is one of the most common and heritable human cancers. Our aim was to find germline biomarkers that can predict disease outcome. We previously detected predisposing signals at 2q37, the location of the prostate specific ANO7 gene. To investigate, in detail, the associations between the ANO7 gene and PrCa risk and disease aggressiveness, ANO7 was sequenced in castration resistant tumors together with samples from unselected PrCa patients and unaffected males. Two pathogenic varian ...[more]