Ontology highlight
ABSTRACT:
SUBMITTER: Rikkert LG
PROVIDER: S-EPMC6590195 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Rikkert Linda G LG van der Pol Edwin E van Leeuwen Ton G TG Nieuwland Rienk R Coumans Frank A W FAW
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20181201 12
Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor-educated platelets (TEPs), tumor-derived extracellular vesicles (tdEVs), EV-associated miRNA (EV-miRNA), and circulating cell-free DNA (ccfDNA). Because the size and density of biomarkers differ, blood is centrifuged to isolate or concentrate the biomarker of interest. Here, we applied a model to estimate the effect of centrifugation on the purity of a biomarker according to published protocols. The model is ...[more]