Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues.
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ABSTRACT:
SUBMITTER: Misawa T
PROVIDER: S-EPMC6590335 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues.
Misawa Takashi T Goto Chihiro C Shibata Norihito N Hirano Motoharu M Kikuchi Yutaka Y Naito Mikihiko M Demizu Yosuke Y
MedChemComm 20190404 6
Antimicrobial peptides (AMPs) have garnered much attention as novel therapeutic agents against infectious diseases. They exhibit antimicrobial activity through microbial membrane disruption based on their amphipathic properties. In this study, we rationally designed and synthesized a series of novel AMPs <b>Block</b>, <b>Stripe</b>, and <b>Random</b>, and revealed that <b>Stripe</b> exhibits potent antimicrobial activity against Gram-positive and Gram-negative microbes. Moreover, we also demonst ...[more]
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