Dataset Information

Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment.

ABSTRACT:

Objective

TARGIT-A randomised women with early breast cancer to receive external beam radiotherapy (EBRT) or intraoperative radiotherapy (TARGIT-IORT). This study aimed to identify what extra risk of recurrence patients would accept for perceived benefits and risks of different radiotherapy treatments.

Methods

Patient preferences were determined by self-rated trade-off questionnaires in two studies: Stage (1) 209 TARGIT-A participants (TARGIT-IORTn = 108, EBRTn = 101); Stage (2) 123 non-trial patients yet to receive radiotherapy (pre-treatment group), with 85 also surveyed post-radiotherapy. Patients traded-off risks of local recurrence in preference selection between TARGIT-IORT and EBRT.

Results

TARGIT-IORT patients were more accepting of IORT than EBRT patients with 60% accepting the highest increased risk presented (4%-6%) compared to 12% of EBRT patients, and 2% not accepting IORT at all compared to 43% of EBRT patients. Pre-treatment patients were more accepting of IORT than post-treatment patients with 23% accepting the highest increased risk presented compared to 15% of post-treatment patients, and 15% not accepting IORT at all compared to 41% of pre-treatment patients.

Conclusions

Breast cancer patients yet to receive radiotherapy accept a higher recurrence risk than the actual risk found in TARGIT-A. Measured patient preferences are highly influenced by experience of treatment received. This finding challenges the validity of post-treatment preference studies.

SUBMITTER: Corica T

PROVIDER: S-EPMC6590655 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment.

Corica Tammy T Saunders Christobel M CM Bulsara Max K MK Taylor Mandy M Joseph David J DJ Nowak Anna K AK

European journal of cancer care 20190114 2

<h4>Objective</h4>TARGIT-A randomised women with early breast cancer to receive external beam radiotherapy (EBRT) or intraoperative radiotherapy (TARGIT-IORT). This study aimed to identify what extra risk of recurrence patients would accept for perceived benefits and risks of different radiotherapy treatments.<h4>Methods</h4>Patient preferences were determined by self-rated trade-off questionnaires in two studies: Stage (1) 209 TARGIT-A participants (TARGIT-IORTn = 108, EBRTn = 101); Stage (2) 1 ...[more]

PMID: 30637839

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Dataset Information

Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment.

Objective

Methods

Results

Conclusions

Publications

Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment.

Similar Datasets

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