Ontology highlight
ABSTRACT:
SUBMITTER: Todd RT
PROVIDER: S-EPMC6591007 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Todd Robert T RT Wikoff Tyler D TD Forche Anja A Selmecki Anna A
eLife 20190607
Genome rearrangements resulting in copy number variation (CNV) and loss of heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and promote rapid adaptation of fungi to novel environments. In the human fungal pathogen <i>Candida albicans</i>, CNV and LOH confer increased virulence and antifungal drug resistance, yet the mechanisms driving these rearrangements are not completely understood. Here, we unveil an extensive array of long repeat sequences (65-6499 bp) tha ...[more]