Ontology highlight
ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC6591025 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20180531 5
The mammalian Target of Rapamycin Complex 1 (mTORC1)-signaling system plays a critical role in the maintenance of cellular homeostasis by sensing and integrating multiple extracellular and intracellular cues. Therefore, uncovering the effectors of mTORC1 signaling is pivotal to understanding its pathophysiological effects. Here we report that the transcription factor forkhead/winged helix family k1 (Foxk1) is a mediator of mTORC1-regulated gene expression. Surprisingly, Foxk1 phosphorylation is ...[more]