Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis.
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ABSTRACT:
SUBMITTER: von Karstedt S
PROVIDER: S-EPMC6591140 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis.
von Karstedt Silvia S Conti Annalisa A Nobis Max M Montinaro Antonella A Hartwig Torsten T Lemke Johannes J Legler Karen K Annewanter Franka F Campbell Andrew D AD Taraborrelli Lucia L Grosse-Wilde Anne A Coy Johannes F JF El-Bahrawy Mona A MA Bergmann Frank F Koschny Ronald R Werner Jens J Ganten Tom M TM Schweiger Thomas T Hoetzenecker Konrad K Kenessey Istvan I Hegedüs Balazs B Bergmann Michael M Hauser Charlotte C Egberts Jan-Hendrik JH Becker Thomas T Röcken Christoph C Kalthoff Holger H Trauzold Anna A Anderson Kurt I KI Sansom Owen J OJ Walczak Henning H
Cancer cell 20150402 4
Many cancers harbor oncogenic mutations of KRAS. Effectors mediating cancer progression, invasion, and metastasis in KRAS-mutated cancers are only incompletely understood. Here we identify cancer cell-expressed murine TRAIL-R, whose main function ascribed so far has been the induction of apoptosis as a crucial mediator of KRAS-driven cancer progression, invasion, and metastasis and in vivo Rac-1 activation. Cancer cell-restricted genetic ablation of murine TRAIL-R in autochthonous KRAS-driven mo ...[more]
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