Ontology highlight
ABSTRACT:
SUBMITTER: Cheng RM
PROVIDER: S-EPMC6591161 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cheng Ruo-Mei RM Tang Xiao-Peng XP Long Ai-Lin AL Mwangi James J Lai Ren R Sun Rui-Pu RP Long Cheng-Bo CB Zhang Zhen-Qing ZQ
Zoological research 20190328 3
Protease inhibitors have been reported rarely from the leech <i>Hirudinaria manillensis</i>. In this study, we purified a novel protease inhibitor (bdellin-HM-2) with anticoagulant properties from <i>H. manillensis</i>. With a molecular weight of 1.4x10<sup>4</sup>, bdellin-HM-2 was also characterized with three intra-molecular disulfide bridges at the N-terminus and multiple HHXDD and HXDD motifs at the C-terminus. cDNA cloning revealed that the putative nucleotide-encoding protein of bdellin-H ...[more]