Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.
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ABSTRACT:
SUBMITTER: Moskalev AA
PROVIDER: S-EPMC6591219 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity.
Moskalev Alexey A AA Shaposhnikov Mikhail V MV Zemskaya Nadezhda V NV Koval Liubov А LА Schegoleva Eugenia V EV Guvatova Zulfiya G ZG Krasnov George S GS Solovev Ilya A IA Sheptyakov Maksim A MA Zhavoronkov Alex A Kudryavtseva Anna V AV
Scientific reports 20190624 1
The E(z) histone methyltransferase heterozygous mutation in Drosophila is known to increase lifespan and stress resistance. However, the longevity mechanisms of E(z) mutants have not been revealed. Using genome-wide transcriptome analysis, we demonstrated that lifespan extension, increase of resistance to hyperthermia, oxidative stress and endoplasmic reticulum stress, and fecundity enhancement in E(z) heterozygous mutants are accompanied by changes in the expression level of 239 genes (p < 0.05 ...[more]
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