Ontology highlight
ABSTRACT:
SUBMITTER: Ge Y
PROVIDER: S-EPMC6591255 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ge Yafang Y Cao Yuzhen Y Yi Guosheng G Han Chunxiao C Qin Yingmei Y Wang Jiang J Che Yanqiu Y
Scientific reports 20190624 1
In this paper, we investigate the abatement of spike-and-wave discharges in a thalamocortical model using a closed-loop brain stimulation method. We first explore the complex states and various transitions in the thalamocortical computational model of absence epilepsy by using bifurcation analysis. We demonstrate that the Hopf and double cycle bifurcations are the key dynamical mechanisms of the experimental observed bidirectional communications during absence seizures through top-down cortical ...[more]