Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

ABSTRACT: Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence sugg

SUBMITTER: Shungin D 

PROVIDER: S-EPMC6591304 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature