About the existence of common determinants of gene expression in the porcine liver and skeletal muscle.

ABSTRACT:

Background

The comparison of expression QTL (eQTL) maps obtained in different tissues is an essential step to understand how gene expression is genetically regulated in a context-dependent manner. In the current work, we have compared the transcriptomic and eQTL profiles of two porcine tissues (skeletal muscle and liver) which typically show highly divergent expression profiles, in 103 Duroc pigs genotyped with the Porcine SNP60 BeadChip (Illumina) and with available microarray-based measurements of hepatic and muscle mRNA levels. Since structural variation could have effects on gene expression, we have also investigated the co-localization of cis-eQTLs with copy number variant regions (CNVR) segregating in this Duroc population.

Results

The analysis of differential expresss

SUBMITTER: Gonzalez-Prendes R 

PROVIDER: S-EPMC6591854 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature