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About the existence of common determinants of gene expression in the porcine liver and skeletal muscle.


ABSTRACT: BACKGROUND:The comparison of expression QTL (eQTL) maps obtained in different tissues is an essential step to understand how gene expression is genetically regulated in a context-dependent manner. In the current work, we have compared the transcriptomic and eQTL profiles of two porcine tissues (skeletal muscle and liver) which typically show highly divergent expression profiles, in 103 Duroc pigs genotyped with the Porcine SNP60 BeadChip (Illumina) and with available microarray-based measurements of hepatic and muscle mRNA levels. Since structural variation could have effects on gene expression, we have also investigated the co-localization of cis-eQTLs with copy number variant regions (CNVR) segregating in this Duroc population. RESULTS:The analysis of differential expresssion revealed the existence of 1204 and 1490 probes that were overexpressed and underexpressed in the gluteus medius muscle when compared to liver, respectively (|fold-change|?>?1.5, q-value?

SUBMITTER: Gonzalez-Prendes R 

PROVIDER: S-EPMC6591854 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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About the existence of common determinants of gene expression in the porcine liver and skeletal muscle.

González-Prendes Rayner R   Mármol-Sánchez Emilio E   Quintanilla Raquel R   Castelló Anna A   Zidi Ali A   Ramayo-Caldas Yuliaxis Y   Cardoso Tainã Figueiredo TF   Manunza Arianna A   Cánovas Ángela Á   Amills Marcel M  

BMC genomics 20190624 1


<h4>Background</h4>The comparison of expression QTL (eQTL) maps obtained in different tissues is an essential step to understand how gene expression is genetically regulated in a context-dependent manner. In the current work, we have compared the transcriptomic and eQTL profiles of two porcine tissues (skeletal muscle and liver) which typically show highly divergent expression profiles, in 103 Duroc pigs genotyped with the Porcine SNP60 BeadChip (Illumina) and with available microarray-based mea  ...[more]

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