FDG PET/CT for the early prediction of RAI therapy response in patients with metastatic differentiated thyroid carcinoma.

ABSTRACT:

Background

In some patients with metastatic differentiated thyroid cancer, even if they had substantial of radioactive iodine (RAI) uptake, the RAI therapy response was poor. We investigated the usefulness of FDG PET/CT for the early prediction of RAI therapy response in the patients with metastatic differentiated thyroid cancer (DTC).

Methods

The 54 metastatic DTC patients who underwent both RAI therapy scan and FDG PET/CT at the same period were enrolled in the study. Clinical information and several parameters from RAI therapy scan and FDG PET/CT were investigated. Therapeutic response of RAI was assessed as two categories: response rate (RR) and disease control rate (DCR).

Results

Twenty-two patients (41%) had therapeutic response to RAI therapy, whereas 32 (59%)

SUBMITTER: Kang SY 

PROVIDER: S-EPMC6592523 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature