Ontology highlight
ABSTRACT:
SUBMITTER: Goodsell DS
PROVIDER: S-EPMC6592547 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Goodsell David S DS Jewett Andrew A Olson Arthur J AJ Forli Stefano S
PLoS computational biology 20190613 6
A coarse-grain computational method integrates biophysical and structural data to generate models of HIV-1 genomic RNA, nucleocapsid and integrase condensed into a mature ribonucleoprotein complex. Several hypotheses for the initial structure of the genomic RNA and oligomeric state of integrase are tested. In these models, integrase interaction captures features of the relative distribution of gRNA in the immature virion and increases the size of the RNP globule, and exclusion of nucleocapsid fr ...[more]