'Online' integration of sensory and fear memories in the rat medial temporal lobe.
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ABSTRACT:
SUBMITTER: Wong FS
PROVIDER: S-EPMC6592679 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
'Online' integration of sensory and fear memories in the rat medial temporal lobe.
Wong Francesca S FS Westbrook R Fred RF Holmes Nathan M NM
eLife 20190610
How does a stimulus never associated with danger become frightening? The present study addressed this question using a sensory preconditioning task with rats. In this task, rats integrate a sound-light memory formed in stage 1 with a light-danger memory formed in stage 2, as they show fear when tested with the sound in stage 3. Here we show that this integration occurs 'online' during stage 2: when activity in the region that consolidated the sound-light memory (perirhinal cortex) was inhibited ...[more]
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