Ontology highlight
ABSTRACT:
SUBMITTER: Lorincz P
PROVIDER: S-EPMC6592680 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lőrincz Péter P Kenéz Lili Anna LA Tóth Sarolta S Kiss Viktória V Varga Ágnes Á Csizmadia Tamás T Simon-Vecsei Zsófia Z Juhász Gábor G
eLife 20190613
Two related multisubunit tethering complexes promote endolysosomal trafficking in all eukaryotes: Rab5-binding CORVET that was suggested to transform into Rab7-binding HOPS. We have previously identified miniCORVET, containing Drosophila Vps8 and three shared core proteins, which are required for endosome maturation upstream of HOPS in highly endocytic cells (Lőrincz et al., 2016a). Here, we show that Vps8 overexpression inhibits HOPS-dependent trafficking routes including late endosome maturati ...[more]