Deep Brain Stimulation in Patients With Mutations in Parkinson's Disease-Related Genes: A Systematic Review.

ABSTRACT:

Background

Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), and careful selection of candidates is a key component of successful therapy. Although it is recognized that factors such as age, disease duration, and levodopa responsiveness can influence outcomes, it is unclear whether genetic background should also serve as a parameter.

Objectives

The aim of this systematic review is to explore studies that have evaluated DBS in patients with mutations in PD-related genes.

Methods

We performed a selective literature search for articles regarding the effects of DBS in autosomal dominant or recessive forms of PD or in PD patients with genetic risk factors. Data regarding changes in motor and nonmotor scores and the presence of adverse eve

SUBMITTER: de Oliveira LM 

PROVIDER: S-EPMC6592794 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature